JPH0140038B2 - - Google Patents

Info

Publication number
JPH0140038B2
JPH0140038B2 JP58214928A JP21492883A JPH0140038B2 JP H0140038 B2 JPH0140038 B2 JP H0140038B2 JP 58214928 A JP58214928 A JP 58214928A JP 21492883 A JP21492883 A JP 21492883A JP H0140038 B2 JPH0140038 B2 JP H0140038B2
Authority
JP
Japan
Prior art keywords
compound
aza
title product
homoerythromycin
deoxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP58214928A
Other languages
English (en)
Japanese (ja)
Other versions
JPS59104398A (ja
Inventor
Maikeru Buraito Jiin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Publication of JPS59104398A publication Critical patent/JPS59104398A/ja
Publication of JPH0140038B2 publication Critical patent/JPH0140038B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Cosmetics (AREA)
JP58214928A 1982-11-15 1983-11-15 エピ化アザホモエリスロマイシンａ誘導体 Granted JPS59104398A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44197982A 1982-11-15 1982-11-15
US441979 1982-11-15

Publications (2)

Publication Number Publication Date
JPS59104398A JPS59104398A (ja) 1984-06-16
JPH0140038B2 true JPH0140038B2 (en]) 1989-08-24

Family

ID=23755068

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58214928A Granted JPS59104398A (ja) 1982-11-15 1983-11-15 エピ化アザホモエリスロマイシンａ誘導体

Country Status (26)

Country Link
EP (1) EP0109253B1 (en])
JP (1) JPS59104398A (en])
KR (1) KR850000968B1 (en])
AT (1) ATE30237T1 (en])
AU (1) AU544790B2 (en])
CA (1) CA1239639A (en])
CS (1) CS241069B2 (en])
DD (1) DD216017A5 (en])
DE (1) DE3374065D1 (en])
DK (1) DK159322C (en])
EG (1) EG16641A (en])
ES (2) ES8600327A1 (en])
FI (1) FI72980C (en])
GR (1) GR79425B (en])
GT (1) GT198304062A (en])
HU (1) HU193886B (en])
IE (1) IE56234B1 (en])
IL (1) IL70228A (en])
NO (1) NO160262C (en])
NZ (1) NZ206259A (en])
PH (2) PH19293A (en])
PL (2) PL143281B1 (en])
PT (1) PT77645B (en])
SU (1) SU1272996A3 (en])
YU (2) YU43198B (en])
ZA (1) ZA838460B (en])

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
WO1989000576A1 (en) * 1987-07-09 1989-01-26 Pfizer Inc. Azithromycin dihydrate
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
YU149889A (en) * 1989-07-26 1991-02-28 Pliva Zagreb Process for preparing biologically active derivatives of tylozine
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065674A1 (en) * 1991-04-10 1992-10-11 Robert R. Wilkening 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
CA2068951A1 (en) * 1991-05-20 1992-11-21 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
AU680356B2 (en) * 1994-05-06 1997-07-24 Pfizer Inc. Controlled-release dosage forms of azithromycin
ES2146886T3 (es) * 1995-06-29 2000-08-16 Texas Biotechnology Corp Inhibidores de la selectina de moleculas pequeñas bivalentes y trivalentes.
HRP960497B1 (en) * 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
JP2003507487A (ja) * 1999-08-24 2003-02-25 アボット・ラボラトリーズ 抗菌活性を有する９ａ−アザライド類
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6586576B2 (en) * 2000-01-04 2003-07-01 Teva Pharmaceutical Industries Ltd Preparation method of azithromycin hydrates
JP2004506664A (ja) 2000-08-23 2004-03-04 ウォックハート・リミテッド 無水アジトロマイシンの製造法
US6852262B2 (en) 2002-05-09 2005-02-08 The Gillette Company Insert molding razor cartridges
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
JP2007513139A (ja) 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
WO2005053656A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
KR100844628B1 (ko) 2003-12-04 2008-07-07 화이자 프로덕츠 인크. 제약상 다입자의 제조 방법
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
RU2256665C1 (ru) * 2004-01-29 2005-07-20 Открытое акционерное общество Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Способ получения оксима эритромицина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
JPS5788193A (en) * 1980-11-21 1982-06-01 Pliva Pharm & Chem Works 11-aza-10-deoxo-10-dihydroerythromycin a, derivatives and manufacture
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Also Published As

Publication number Publication date
CS241069B2 (en) 1986-03-13
IL70228A (en) 1987-03-31
ES527249A0 (es) 1985-10-01
NO834146L (no) 1984-05-16
JPS59104398A (ja) 1984-06-16
EP0109253A2 (en) 1984-05-23
NZ206259A (en) 1986-08-08
PL244557A1 (en) 1985-03-26
ES543638A0 (es) 1986-01-16
YU43198B (en) 1989-04-30
YU224383A (en) 1986-04-30
FI834163A0 (fi) 1983-11-14
ES8604257A1 (es) 1986-01-16
HUT35273A (en) 1985-06-28
FI72980B (fi) 1987-04-30
EP0109253B1 (en) 1987-10-14
IE56234B1 (en) 1991-05-22
ATE30237T1 (de) 1987-10-15
HU193886B (en) 1987-12-28
PL250350A1 (en) 1985-04-24
AU544790B2 (en) 1985-06-13
CA1239639A (en) 1988-07-26
DK159322B (da) 1990-10-01
IE832652L (en) 1984-05-15
DE3374065D1 (en) 1987-11-19
EP0109253A3 (en) 1984-09-12
KR840006673A (ko) 1984-12-01
DK518683A (da) 1984-05-16
EG16641A (en) 1990-08-30
YU43425B (en) 1989-06-30
YU197285A (en) 1986-08-31
NO160262B (no) 1988-12-19
PH21560A (en) 1987-12-11
PT77645A (en) 1983-12-01
DK518683D0 (da) 1983-11-14
NO160262C (no) 1989-03-29
DD216017A5 (de) 1984-11-28
PL143281B1 (en) 1988-01-30
SU1272996A3 (ru) 1986-11-23
PT77645B (en) 1986-05-12
PH19293A (en) 1986-03-04
IL70228A0 (en) 1984-02-29
ZA838460B (en) 1985-06-26
FI72980C (fi) 1987-08-10
DK159322C (da) 1991-02-25
AU2130983A (en) 1984-05-24
PL142601B1 (en) 1987-11-30
ES8600327A1 (es) 1985-10-01
FI834163L (fi) 1984-05-16
CS845583A2 (en) 1985-07-16
GT198304062A (es) 1985-05-04
GR79425B (en]) 1984-10-22
KR850000968B1 (ko) 1985-07-02

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees